PLOD2 catalyzeslysyl hydroxylation on the Gly-X-Y motif of collagen peptides andis required for the formation of stabilized collagen cross-links. Given these functions, it is perhaps not surprisingthat PLOD2 is critical for epithelial mesenchymal transition (EMT),migration, and metastasis of various cancers,, as well as tissue repair and fibrosis, though no selective inhibitors have been reported. Here, PLOD2 is linked to cancer.