Therefore,sulfonamido (CA-SF) and arylureidosulfamido functionalized carboraneshave been already proposed as both CA IX inhibitors−,  and boron deliveryagents., Despite the positive results achieved ininhibiting mesothelioma cell proliferation, the low solubility inwater and the inability to monitor their biodistribution prior totreatment are the main limitations for the clinical translation ofthese compounds. Here, CA9 is linked to mesothelioma.