Prior studies have established that hypoxia-induced upregulationof PD-L1 enhances tumor immune evasion and fosters an immunosuppressiveTME, ultimately conferring resistance to PD-L1 blockade therapy.−, ,  In this context, NP1192 was shown to reverse the hypoxic microenvironmentin CCa, thereby achieving tumor suppression in vitro. This evidence concerns the gene CD274 and neoplasm.