CD8A and neoplasm: Ifn-γ-producing EF-likeCD8+ TILs infiltrate the tumor-associated immune milieuand constitute a considerable population of CD8+ TILs,demonstrating the ability of NP1192 to mediate immune-mediated killingprograms (Figure F).Subsequently, we examined whether targeting NAT10 could influencethe developmental trajectory of these CD8+ TIL subtypes.Pseudotime analysis revealed that the naive, cytotoxic effector-Ifn-γand proliferating subtypes accounted for the main proportions in theinitial state, whereas the Tex subtypes were maintainedin the advanced stage.