As a key immune checkpoint molecule, PD-L1 contributesto tumor immune evasion by binding to the PD-1 receptor on T cells,thereby inhibiting T cell activation, proliferation, and cytotoxicfunction.−,  The above results indicate that NAT10 promotes tumorimmune evasion via HIF-1α-mediated PD-L1 up-regulation. This evidence concerns the gene CD274 and neoplasm.