IFNAR1 and neoplasm: It should be noted thatwhen type-I IFN signaling was inhibited with anti-IFNAR1 mAb, we stillobserved the suppression of tumor growth (Figure S12B), demonstrating the similar pattern reported for doxorubicin-inducedICD. The results suggest that cytotoxicityand immunogenicity are complementary, rather than mutually exclusive.R.E may accomplish the immediate elimination of susceptible cancercells, while the subsequent MDA5-dependent secretion of IFN-βfacilitates dendritic-cell cross-priming and sustained CD8+ T-cell-mediated tumor control.