Furthermore,R.E selectively induced IFN-β secretion in cancer cells (B16F10and CT26 colorectal carcinoma) in a dose-dependent manner, while normalcells (NIH3T3 and HaCaT keratinocytes) showed no significant response,suggesting its tumor-specific immune modulatory properties (Figure C). This evidence concerns the gene IFNB1 and colorectal carcinoma.