HMGB1 and cancer: In addition to the action of IFN-β, the R.E-induced immunogenicdeath of cancer cells releasing ATP and HMGB1 (Figure B) can also contribute to the recruitmentand activation of DCs in the TME and promote the uptake of dying tumorcells and presentation of tumor antigens by DCs. This enhanced antigen presentation and T cell activationin the TME and TDLN would further evoke the systemic anticancer immunity.