Based on theresults, we hypothesized that R.E might have further immune modulatoryproperties and initially examined the R.E-induced transcriptionalchanges by performing RNA sequencing-based transcriptomic profilingon murine melanoma cells (B16F10) and murine embryonic fibroblastcells (NIH3T3) treated with R.E. We observed a substantial elevationin Ifnb1 gene expression, particularly in cancer cells (Supporting Information, RNA-seq data). Here, IFNB1 is linked to melanoma.