IFNA1 and cancer: Interestingly,this pattern of transcriptional change resembles that induced by doxorubicin,which triggers a signal relay to induce IFN-α by binding toTLR3, leading to IFN-α/β production and CXCL10 release. However, as shown in Figure L, while R.E-treated cancer cells had a transcriptionalprofile closer to that of doxorubicin-treated cells than to that ofR.E-treated normal cells, the profile of R.E was distinct from thatof doxorubicin.