NFKB1 and inflammatory bowel disease: Experimental evidence from animal models of inflammatory bowel disease (IBD), psoriasis, osteoarthritis, and experimental autoimmune encephalomyelitis (EAE) has confirmed that AKBA-mediated suppression of the NF-κB pathway contributes to its anti-inflammatory effects (Wang et al., 2009; Nadeem et al., 2022; Zhou et al., 2022; Zhang and Jiang, 2023).