The inflammatory factors released by sepsis itself, such as TNF - α and IL-1, can activate the oxidative stress pathway and injury renal tubular cells; NE helps maintain effective perfusion pressure, thereby improving glomerular filtration rate, mitigating tubular cell damage and reducing the risk of acute kidney injury (AKI) (Al-Husinat et al., 2023). This evidence concerns the gene TNF and acute kidney injury.