This work investigatesthe codelivery of CpG oligodeoxynucleotides(CpG ODN) and plasmid encoding a model antigen (pOVA) to activatedendritic cells (DCs) in the context of cancer vaccination, usingnucleic acid-polycation mannosylated glycoplexes designed to targetthe endocytic receptor CD206 on DCs. The gene discussed is MRC1; the disease is cancer.