CD274 and neoplasm: More importantly, phototherapy-induced ICD and reversed hypoxia-induced immunosuppressive TME of RuIP nanohybrids allow activate stronger immune responses compared to free IR825, re-programming immunosuppressive, pro-tumoral M2 macrophages to immune-activated, antitumor M1 macrophages, downregulates PD-L1 expression, recruit a large number of immune cells, leading to significant metastatic tumor inhibition.