PPARG and obesity due to melanocortin 4 receptor deficiency: Carriers of the rs1059491G allele in the sulfotransferase family 1A member 2 (SULT1A2) gene exhibited a 54% reduction in overweight/obesity risk compared to non-carriers, a phenomenon potentially mediated through its location within the PPARγ2 and RXRA transcription factor binding sites (64).