RXRA and obesity due to melanocortin 4 receptor deficiency: Belongs to the sulfotransferase (SULT) superfamily; catalyzes sulfonation of phenolic compounds, participating in phase II metabolic detoxification; maintains endocrine homeostasis by metabolizing hormones (e.g., estrogens and 17β-estradiol); encodes heat-resistant diphenol sulfotransferase, a key enzyme in sulfuric acid metabolism; located at transcription factor binding sites of PPARγ2 and RXRA, potentially regulating lipid metabolism and obesity