Hypoxia-inducible factor 1 alpha (HIF1α), a key transcription factor mediating hypoxic responses and metabolic reprogramming in tumor cells (52), plays a critical role in lipid metabolism—promoting fatty acid synthesis, inhibiting lipolysis and fatty acid oxidation, and enhancing cholesterol metabolism—beyond its established functions in glucose metabolism and angiogenesis. Here, HIF1A is linked to neoplasm.