AR and Alzheimer disease: Plasmalogen deficiency is known to aggravate the disease symptoms, amplifying AD in the brain.67 Just like plasmalogens, peroxisomal disruption alters ether lipid levels.61 A study on physiological changes that take place in ether-lipid-deficient mice showed disturbed androgen-dependent regulation.68 In the case of AD, abnormal ether lipid levels have also been studied,69 but the exact role of AR in regulating plasmalogens and ether lipids is yet to be consolidated.