The cross talk between AR and PI3K/AKT/mTOR as well as MAPK pathways has been extensively studied in cases of Polycystic ovary syndrome PCOS,28 prostate,29 and breast cancer,30 where such cross talks and reciprocal feedback loops with blockade of one lead to stimulation of the other and thus influence disease progression and recurrence. This evidence concerns the gene AKT1 and polycystic ovary syndrome.