CD36 and metabolic syndrome: Deficiency in CD36 is known to cause dyslipidemia, subclinical inflammation, and metabolic disorders, which are established risk factors for atherosclerosis.19 Abnormally up-regulated CD36 also promotes inflammation, foam cell formation, endothelial apoptosis, macrophage trapping, and thrombosis.20 Any form of imbalance in CD36 levels alters the lipid uptake, and a study by Grajchen et al (2020)21 demonstrated that the lipid entry into the cell is dependent on the functioning of the NRF2 gene.