Beyond detecting MDP and triggering the pro‐inflammatory response, NOD2 protein has recently been associated with the development of Crohn′s disease, as well as oxidative stress and insulin resistance (Denou et al. 2015; Maurya et al. 2015; Mohanan and Grimes 2014; Tamrakar et al. 2010). Here, NOD2 is linked to Insulin resistance.