SALL4 and gastric cancer: Evidence shows that when SALL4 levels are high, the Wnt/β-catenin signaling pathway will be triggered, potentially due to the upregulation of the SALL4 co-expressed gene TRIB3, which is linked to the genesis of GC.14 Moreover, SALL4 accelerated GC progression by regulating hexokinase 2 (HK-2) and enhancing glycolysis.15