Representative flow cytometry profiles of LOX-1+PMN-MDSC in the blood of a responsive and a non-responsive (R/M) HNSCC patient at T0 and T1 are shown in Fig. 6D. Functional activity of LOX-1+PMN-MDSCs at T1 again indicated that this subset maintained its suppressive capacity (Additional file 4). This evidence concerns the gene OLR1 and head and neck squamous cell carcinoma.