CRP and stroke disorder: At the subtype level, BMI had a negative causal relationship with all five DR subtypes, CRP had a negative causal relationship with DR-BKG, HBP showed a positive causal relationship with both DR-BKG and DR-NAS, SBP had a negative causal relationship with both DR and DR-BKG, and Stroke had a negative causal relationship with DR-PROLIF.