It directly binds to and regulates the function of caspase-8 [15, 31, 62], of proteasome-mediated RIPK1 stability in amyotrophic lateral sclerosis [31], as well as vesicle trafficking and autophagy, and therefore represents a promising regulator of vesicular ADAM15 [35, 53]. The gene discussed is CASP8; the disease is amyotrophic lateral sclerosis.