Analysis of the TCGA database revealed that ITGB2 (Log2FC = −0.62, pFDR = 3.53 × 10−5), SEPTIN3 (Log2FC = 1.54, pFDR = 2.03 × 10−13) and AGRN (Log2FC = 0.56, pFDR = 5.41 × 10−6) exhibited different expression between lung adenocarcinoma and normal tissues, consistent with results of observational and genetic studies (Figure 4A and Table S15). This evidence concerns the gene ITGB2 and lung adenocarcinoma.