Analysis of the TCGA database revealed that ITGB2 (Log2FC = −0.62, pFDR = 3.53 × 10−5), SEPTIN3 (Log2FC = 1.54, pFDR = 2.03 × 10−13) and AGRN (Log2FC = 0.56, pFDR = 5.41 × 10−6) exhibited different expression between lung adenocarcinoma and normal tissues, consistent with results of observational and genetic studies (Figure 4A and Table S15). Here, SEPTIN3 is linked to lung adenocarcinoma.