For the significant proteins identified in the observational analyses, Agrin (AGRN), CD5 antigen‐like (CD5L), glucosamine‐6‐phosphate isomerase 1 (GNPDA1), integrin beta‐2 (ITGB2) and neuronal‐specific septin‐3 (SEPTIN3) remained associated with lung adenocarcinoma in the two‐sample MR analyses. Here, CD5L is linked to lung adenocarcinoma.