Additionally, the presence of nucleolar pTDP-43 aggresomes in the LATE and AD ± LATE but not in the FTLD-TDP cohort, as well as their presence in the AD + LBD and LBD cohorts but not in FTLD-Tau cases, suggests that nucleolar sequestration of pTDP-43 into aggresomes may emerge from a combined pathological burden. Here, MAPT is linked to Alzheimer disease.