When staging the AD tau cases as 0–3 depending on the absence (0) or the most advanced type of nucleolar aggregate observed in the tissue (1 = the presence of multiple small nucleolar foci, 2 = a mix of small foci and larger aggregates, and 3 = having large, central nucleolar aggresomes), there was a significant positive correlation between the advancement of pTau nucleolar aggregates and the burden of Aβ plaque (A score, p value 0.0455) (Fig. 7c). This evidence concerns the gene MAPT and Alzheimer disease.