FUS and Alzheimer disease: However, both AD cohorts—AD ± LATE and AD + LBD—presented multiple small nucleolar foci (6.5% and 11%, respectively) and central, large nucleolar pTau aggresomes (13% and 11%, respectively), while LBD, FTLD-Tau and FTLD-FUS cohorts only displayed pTau aggresomes (3.5%, 6% and 40%, respectively).