Using Congo red staining in postmortem brain sections from the temporal cortex from aged controls (N = 5) and a variety of neurodegenerative diseases—LATE (N = 5), pure AD (N = 4), AD + LATE (N = 5), AD + LBD (N = 5), pure LBD (N = 5), FTLD-Tau (N = 5), FTLD-TDP (N = 5), and FTLD-FUS (N = 5) (cohorts drawn from the larger set of cases outlined in supplementary Table 1)—we confirmed the amyloid nature of neuronal nucleolar aggregates observed in all neurodegenerative diseases examined as well as in aged controls (only one had no age-related pathologies). Here, FUS is linked to neurodegenerative disease.