Clinical cases without neurofibrillary tangles (no tau cohort) had all three types of nucleolar pTau aggregates—multiple small foci (4.8%), combination of both types (9.5%) and pTau aggresomes (14%)—whereas AD tau and 4R tau cohorts display smaller proportions of nucleolar pTau foci (in AD tau only, 4%) and aggresomes (9.3% and 8.3%, respectively). The gene discussed is MAPT; the disease is Alzheimer disease.