The models showed very good discriminative performance in MEMENTO but poor performance in AIBL (any-cause dementia model including GFAP, Harrell’s C = 0.77 in MEMENTO, 0.56 in AIBL; AD dementia model including pTau181 and GFAP, C = 0.81 in MEMENTO, 0.55 in AIBL; any-cause dementia model including pTau217, C = 0.54 in AIBL, not performed in MEMENTO, eTables 7–9). This evidence concerns the gene GFAP and dementia.