An example of the effectiveness of the cooperation between anti-PD-1-antibody and a “non-canonical ferroptotic- actors” regards the targeting of phosphoglycerate mutase 1 (PGAM1), an enzyme overexpressed in various human cancers, including hepatocellular carcinoma (HCC) [123] and which plays a crucial role in tumor progression through its metabolic mechanism [124]. The gene discussed is PDCD1; the disease is cancer.