Mechanistically, SC suppressed the proliferation of human osteosarcoma MG-63 cells and induced cell cycle arrest by suppressing PI3K/AKT activation, thereby inhibiting the PI3K/Akt/mTOR signaling pathways and modulating energy metabolism through p53-dependent pathways to promote apoptosis in breast cancer cells [75–77]. The gene discussed is AKT1; the disease is breast cancer.