In hepatocellular carcinoma, CTD impeded cell proliferation and induce apoptosis by targeting the Eph receptor B4 (EphB4), as well as inhibiting the janus kinase 2 (JAK2)/signal transducer and activator of signal transducer and activator of transcription 3 (STAT3) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) pathways [46, 47], and CTD regulated EZH2/H3K27 methylation pathway improved immunity [48, 49]. Here, AKT1 is linked to hepatocellular carcinoma.