NOD2 and neoplasm: By contrast, MAMP/translocation axes act as punctate, contextual “danger” cues whose benefits are maximized when (i) structural agonism is favorable (for example, hexa-acylated LPS), (ii) exposure can be localized (tumor or draining nodes), and (iii) the engaged PRR skews toward antitumor immunity (for example, NOD2 over NOD1 in CRC).