We validated our findings by utilizing RCAS virus-mediated induction of oncogenic PDGFB expression and knockdown of Tp53 in SVZ cells of mice expressing the tv⁃a receptor under the Nestin promoter (Ntv-a), resulting in tumors that resemble human oligodendroglioma and display a high-grade histology36,37. This evidence concerns the gene PDGFB and oligodendroglioma.