MKI67 and neoplasm: Whereas we found cluster st_Hyp to overlap with hypoxic, PIM+ areas, and to feature a generally hypoxic tumor cell expression signature, these zones were surrounded by Ki67+ st_Prol spots of a dominant proliferation profile that highly correlated with our scRNA-seq proliferation signatures of clusters CT I-IV (Figs. 5C and S11A, B).