Moreover, measurements based on the labeling of the endothelium with antibodies directed against Podocalyxin and PECAM1 provided evidence of structural differences between the Pdgfbret/ret and Pdgfbret/+ glioma vasculature, as we found vessel area, vessel length, and number of junctions to be significantly higher in pericyte-poor tumor tissue (Figs. 4A, B and S5C). This evidence concerns the gene RET and central nervous system cancer.