METTL14 and rheumatoid arthritis: This study reveals a novel pathway wherein USP5 stabilizes METTL14 through the inhibition of METTL14 ubiquitination, allowing METTL14 to enhance m6A modification of GLUT1 mRNA and ultimately enhancing GLUT1-dependent glycolysis and inflammatory activation in RA-FLSs (Fig. 7).