TMOD3 and cancer: Tmod3 is an actin-binding protein that is widely expressed in human tissues and contributes to various life activities, including maintaining cytoskeletal stress fibers, regulating pseudopodia, maturing oocytes, and facilitating cell secretion.35 A recent study indicated that high Tmod3 expression is notably involved in the occurrence and progression of cancer.23 Gene expression profiling interactive analysis (GEPIA) revealed a positive relationship between the mRNA expression levels of Tmod3 and CDC6 (Fig. 4d).