CDC6 and cancer: Among the various microenvironmental factors affecting cancer cell resistance, cell adhesion has gradually emerged as a crucial determinant, but the underlying mechanisms remain elusive.46 Recently, the development of CRISPR-Cas9 screening has provided a promising strategy for discovering drug resistance related genes, through which we identified CDC6 as the most critical gene associated with cell adhesion-mediated paclitaxel resistance in A549/PTX cells.