Functional analyses demonstrated that tTmod3-N and tTmod3-C regulate cancer cell proliferation and invasion via the nuclear SND1/RhoA pathway and cytoplasmic actin remodeling, respectively.25 Furthermore, Tmod3 promotes F-actin polymerization to facilitate the fusion of autophagosomes with lysosomes, a process that ultimately inhibits ferroptosis and confers cellular resistance to PD-1 antibody therapy.26 Nevertheless, it remains unclear whether Tmod3 is associated with paclitaxel resistance, and the potential relationship between Tmod3 and CDC6 has not been elucidated. The gene discussed is CDC6; the disease is cancer.