CXCL8 and Ventricular arrhythmia: Patients with structural heart disease (AUC = 0.85, IL6) and ventricular arrhythmias (AUC = 0.82, IL6) showed cytokine levels comparable to the whole cohort and a better prediction.<h4>Conclusion</h4>Among the evaluated cytokines, IL8 exhibited the strongest predictive benefit for weaning failure, especially on Day 1.