Using a logistic regression analysis model adjusting for age and comorbidities(including chronic infections, malignancies, and autoimmune diseases), NFE2 gene mutation was identified as an independent determinant of elevated tumor necrosis factor-alpha(TNF-α)(OR=2.747, 95%CI:1.143–6.605, P=0.024), interferon-gamma(IFN-γ)(OR=2.689, 95%CI:1.191–6.076, P=0.017), IL-10(OR=3.219, 95% CI:1.343–7.717, P=0.009), IL-12P70(OR=3.397, 95%CI:1.003–11.508, P=0.049), IL-17(OR=2.284, 95%CI:1.017–5.127, P=0.045). This evidence concerns the gene TNF and autoimmune disease.