Similarly, although CTCF mutations and reduced CTCF binding have been implicated in neurodevelopmental disorders wherein neurons acquire high levels of DSBs, such as Alzheimer’s disease, their impact on the DDR has not been investigated (Dileep et al, 2023; Patel et al, 2023; Zhang et al, 2024). Here, CTCF is linked to early-onset autosomal dominant Alzheimer disease.