While no candidate interactors exhibiting increased binding to the two neuromuscular disease-causing ARD mutants (TRPV4R269C, TRPV4R315W) relative to the TRPV4WT-ARD and the skeletal dysplasia-causing mutant TRPV4D333G-ARD were identified, 21 proteins exhibited reduced interactions with the neuromuscular disease mutants. Here, ADI1 is linked to neuromuscular disease.