YAP has a non-transcriptional function in mitosis, as it is phosphorylated by CDK1 (29), regulates the spindle checkpoint (30), colocalizes with the mitotic spindle and midbody in lung cancer cells (31), is essential for the proper organization of the cytokinesis apparatus (32), and induces mitotic rounding in adult cardiomyocytes (33). The gene discussed is YAP1; the disease is lung carcinoma.