Moreover, KD of HNF1A, 53BP1, or p53 reduced MAOB messenger (m)RNA expression in Caki-1/MAOB cells (Fig. 6M), suggesting that p53 activation induced by MAOB may exert a positive feedback regulatory effect on MAOB expression in ccRCC cells. The gene discussed is HNF1A; the disease is nonpapillary renal cell carcinoma.