According to a False Discovery Rate (FDR) method-corrected threshold (αFDR = 0.05), HOMA index (MMS: t = 2.28, pFDR = 0.024, η2p = 0.04; Maintain: t = 2.33, pFDR = 0.023, η2p = 0.08), and leptin (MMS: t = 4.43, pFDR = 4.3·10−5, η2p = 0.14; Maintain: t = 1.91, pFDR = 0.041, η2p = 0.06), showed significant positive links to brain-PAD in both trials, fetuin B did so in Maintain (t = 2.57, pFDR = 0.023, η2p = 0.11). Here, LEP is linked to peripheral arterial disease.