As with normal menopause, it is associated with abnormally high levels offollicle-stimulating hormone (FSH: >25 IU/L) and luteinizing hormone (LH) due tothe loss of central negative feedback by ovarian steroid and peptide hormones.Secondary (i.e., hypogonadotropic or central) hypogonadism resultsfrom ovarian under-stimulation due to inadequate gonadotrophin secretion, whichtranslates into low (or inappropriately normal) FSH and LH levels with low estradioland/or a thin endometrium. Here, PLOD1 is linked to hypogonadism.