It was also demonstratedthat CYP27B1 knockout mice presented lower leptin levels and consumedsignificantly more food than their wild type counterparts (73,74), and targeted expression of human vitaminD receptor in adipocytes reduced lipolysis, fatty acid beta-oxidation andinduced obesity in mice (75). The gene discussed is CYP27B1; the disease is obesity due to melanocortin 4 receptor deficiency.