Recently, inflammation biomarkers have been utilized as molecular tools for diagnosing periodontal disease, with CX3CL1 and its receptor CX3CR1 considered potentially significant markers.37 CX3CL1 and CX3CR1 are involved in both acute and chronic inflammatory processes, amplifying inflammation and exacerbating disease outcomes.5 To date, few studies have focused on the role of the CX3CL1–CX3CR1 axis in periodontitis. Here, CX3CL1 is linked to periodontitis.