These pathways interact with epithelial cells and macrophages, thereby altering ECM deposition.12 Considering these processes, our study aimed to reveal the role of CX3CL1 in the pathogenesis of GO and its relationship with TNF-α and TGF-β, which are known to participate in inflammatory and fibrotic processes. The gene discussed is CX3CL1; the disease is geroderma osteodysplastica.