Interestingly, the proteome of the acquired enamel pellicle of gastroesophageal reflux disease patients without erosive tooth wear showed an increased expression of various subunits of Hb, different isoforms of cystatin, as well as albumin, when compared to gastroesophageal reflux disease patients with erosive tooth wear (.8 The gene discussed is CST4; the disease is gastroesophageal reflux disease.