Considering phosphorylation have significant impacts on various viral proteins, including SARS-CoV-2 nucleocapsid protein [55,56], influenza A virus NS1 and PA proteins [57,58], HIV-1 envelope glycoprotein 120 (gp120) [59], and HSV-1 US3 and UL13 proteins [60,61], etc., regulating their localization, stability, enzymatic activity and functions, which suggests phosphatases might participate in various viral infection, broadening our understanding of phosphatases and providing a potential therapeutic target for the treatment of diseases induced by viral infection. Here, RPL13A is linked to viral infectious disease.