Originally classified as “platelet-normal VWD1” [32], Vicenza-type VWD exhibits a unique phenotype: severe plasma VWF deficiency with normal VWF platelet stores, preserved large multimers [33] but defective RIPA, hallmarks that prompted its reclassification as type 2M. The gene discussed is VWF; the disease is hyperinsulinemic hypoglycemia, familial, 4.