RB1 and neoplasm: daf-2/InsR, daf-16/FoxO, daf-18/PTEN, lin-35/Rb, fasn-1/FAS, and WNT signaling all modulate formation of starvation-induced gonad abnormalities, and their homologs affect tumor development in mammals, suggesting that homologs of other genes that promote or suppress tumor formation could affect starvation-induced abnormalities [27–31].