CASP8 and cancer: These pathways regulate programmed cell death and the immune response and include key developmental and cancer-associated genes such as cdkn1a, casp8, mdm2, bcl3, pou2f2a, irf9, gad45aa and mmp9 as well as the cbx7a component of the PRC1 complex which showed the greatest change in expression upon dancr loss-of-function.