This includes the CDKN1A mediator of p53-dependent cell cycle arrest and apoptosis that was identified as a common target in both loss-of-function models, as well as caspase family members (CASP7 in human; casp8 in zebrafish) and matrix metalloproteinase genes involved in skin biology, apoptosis and melanoma metastasis (MMP8 and MMP15 in humans; mmp9 and mmp13a in zebrafish). The gene discussed is MMP8; the disease is melanoma.