Orosomucoid-like protein 3 (Ormdl3) gene which is associated with asthma have been found to alter sphingolipid levels including CER, and augmented the expression of pyroptotic markers such as NLRP3 and GSDM-D in lung tissues of obese asthmatic mice and human bronchial epithelial cells [49–51]. This evidence concerns the gene GSDMD and asthma.