Recently, a study reported that ceramide synthase 5 (CerS5), a critical enzyme for C16 ceramide synthesis plays a crucial role in the valvular interstitial cells (VIC) and high‐fat/high‐cholesterol diet (HFHCD) fed mice during the development of aortic valve stenosis and inflammation [9]. This evidence concerns the gene CERS5 and aortic valve stenosis.