Enzymatically derived peptides demonstrate potent health-promoting effects, with antioxidant capacities comparable to or exceeding vitamins C and E, ACE-inhibitory peptides lowering blood pressure in preclinical models, and clinical trials showing that daily supplementation with 10 g fish collagen peptides for 8–12 weeks improves skin hydration, elasticity, wrinkle reduction, and reduces osteoarthritis-related joint pain. This evidence concerns the gene ACE and osteoarthritis.