COBL and hepatocellular carcinoma: Notably, Cobl, a novel actin nucleating factor, dynamically influences neuronal morphology by regulating actin (Ahuja et al. 2007); Pigl encodes a key enzyme in the GPI-anchor biosynthesis pathway, which is involved in the attachment of GPI-anchor to target proteins (Álvarez-Sánchez et al. 2024); and Ssr2, a critical gene involved in protein folding and processing within the endoplasmic reticulum, functions as an oncogene in hepatocellular carcinoma (Chen et al. 2022), all exhibited over fourfold reduction in transcriptional expression following 4 h of OCT4 degradation.