POU5F1 and neoplasm: Additionally, we observed multiple genes that were upregulated more than twofold after four hours of OCT4 degradation, including Kitl (known as stem cell factor) (Chang et al. 2020), Glrx (closely associated with the tumor immune microenvironment) (Chang et al. 2020), Wnt7b (involved in regulating the Wnt signaling pathway) (Liu et al. 2022; Lv et al. 2018), and Camk2n1 (which has cancer-suppressing functions) (Zhang et al. 2022b).