In autoimmune disorders such as SLE, ANCA-associated vasculitis, RA, Gout, and psoriasis, defective NETs clearance and exposure of autoantigens like citrullinated histones, MPO, and PR3 contribute directly to loss of immune tolerance and sustained inflammation [63]. This evidence concerns the gene PRTN3 and anti-neutrophil cytoplasmic antibody-associated vasculitis.