Intracranial progression-free survival was significantly decreased in patients with KPS <70 (p = 0.01), multiple brain metastases (p = 0.036), and GPA scores of 0-1.0 (p = 0.011).<h4>Conclusions</h4>Both GPA and molGPA were validated as significant predictors of OS in patients with melanoma-associated BM. This evidence concerns the gene GYPA and melanoma.