FOXA1 and colorectal carcinoma: On the other hand, ectopic expression of FOXA1 in the mesenchymal-like CRC cell-lines SW480 and SW620 promoted a transition from a mesenchymal to an epithelial morphology (spindle-shaped cells with a scattered growth pattern became tightly packed, cobble-stone like cells), indicating that FOXA1 induces MET in CRC cells (Fig. 4d, Fig. S4a).