Therefore, we analyzed whether the down-regulation of RBM47 is associated with methylation of CpG residues within the vicinity of the TSS of RBM47. First, 53 CRC cell lines were grouped into epithelial- and mesenchymal-like cell lines, according to the expression of CDH1 and VIM (data from the Cancer Cell Line Encyclopedia (CCLE)): thereby 45 cell lines were classified as epithelial-like (high expression of CDH1 and low expression of VIM) and 8 cell lines as mesenchymal-like (low expression of CDH1 and high expression of VIM) (Fig. 6a). This evidence concerns the gene CDH1 and cancer.