To determine whether B cell-intrinsic IL-17RA signaling was required for optimal establishment of chronic MHV68 infection, viral latency and reactivation were measured at 16 days post-infection, the peak of viral latency (3), in the spleen and peritoneal cavity of CD19 Cre-positive and CD19 Cre-negative littermates. This evidence concerns the gene IL17RA and infection.