Loss of B cell-intrinsic IL-17RA signaling during MHV68 infection resulted in a decrease in splenomegaly (Fig. 3A), with a significant reduction in the frequency (Fig. 3B) and total number (Fig. 3C) of overall B cells in the spleen of infected CD19 Cre-positive mice compared to CD19 Cre-negative mice. This evidence concerns the gene CD19 and infection.