This study is the first, to our knowledge, to directly examine the B cell-intrinsic role of IL-17RA signaling in the context of viral infection and show a role for it in the establishment of MHV68 latent infection, the MHV68-driven germinal center response, and expansion of both B-1a and B-b B cells. The gene discussed is IL17RA; the disease is disease arising from reactivation of latent virus.