McCormick et al. reported that RIPK1 expression was down-regulated in head and neck squamous cell carcinoma, suggesting that downregulation of RIPK1 expression promoted by epigenetic changes during tumour progression allows tumour cells to escape anoikis, which may stimulate tumorigenesis by enhancing the metastatic capacity of tumour cells.75 The gene discussed is RIPK1; the disease is head and neck squamous cell carcinoma.