Interestingly, in a lung cancer study, mice deficient in RIPK1 kinase activity (Ripk1K45A/K45A) exhibited a 38.3% reduction in tumour nodules compared with wild-type mice, whereas no difference in the number of tumour nodules was observed in mice with RIPK3 kinase deficiency (Ripk3K51A/K51A).85 This evidence concerns the gene RIPK1 and neoplasm.