GLI1 and chronic kidney disease: Natural compounds also offer potential, as demonstrated by Lobetyolin, which has been shown to alleviate ferroptosis and muscle wasting in a chronic kidney disease model by activating the Hedgehog-GLI1 signaling pathway (116, Lobetyolin Alleviates Ferroptosis of Skeletal Muscle in 5/6 Nephrectomized Mice via Activation of Hedgehog-GLI1 Signaling).