However, in studies of type 2 diabetes caused by hepatitis C virus infection, it is shown that KCNQ1OT1 was found to promote the scorch death of β-cells infected by hepatitis C virus through the miR-223-3p/NLRP3 axis, thereby affecting insulin production and accelerating the onset of diabetes and (66). This evidence concerns the gene NLRP3 and diabetes mellitus.