Apart from the AR, rapid effect exerted at the cell membrane, several proteins have been proposed as membrane androgen receptors, such as the transient receptor potential melastatin 8 (TRPM8), a calcium channel, or the G protein-coupled receptors GPRC6A, and the Oxoeicosanoid receptor 1 (OXER1), to which T present high affinity and exhibit effects in cancer cells (88). The gene discussed is AR; the disease is cancer.